Nuclear magnetic resonance (NMR) spectroscopy is a solution-based technique used to probe the structure and dynamics of molecules, ranging from small molecules to proteins. The NMR facility at MUSC comprises three NMR spectrometers with field strengths of 400, 600 and 850 MHz. The 400 MHz spectrometer is used mainly for small molecule analysis and has two broadband probes. The 600 MHz spectrometer is primarily used for biomolecular research, including solving high-resolution structures of macromolecules, measuring drug/protein interactions and metabolomics. The 850 MHz spectrometer is the most powerful NMR spectrometer in the State of South Carolina and is primarily used for structure elucidation of macromolecular complexes, molecular dynamics and structures of intrinsically unfolded proteins. The facility is housed within a custom-built laboratory on the first floor of the Drug Discovery Building.

The NMR facility can be accessed in two ways: (1) Trained users can access the spectrometers on an hourly-fee basis, or (2) For those without NMR expertise, experiments can be performed by the Facility Manager, in which case additional fees will apply to cover time spent. For extended projects, a percentage effort coverage of the Facility Manager can be negotiated.



Contact Information

Director: Dr. Pat Woster

woster@musc.edu 


Director of the 850 MHz magnet: Dr. Mark Hamann

hamannm@musc.edu


Address

Department of Drug Discovery and Biomedical Sciences

College of Pharmacy

70 President Street

Charleston, SC 29425

Services & Pricing

Effective September 1st, 2018, the instrument charges for MUSC users of the NMR facility are:
Services
850 and 600 MHz magnets, $8/hour
400 MHz magnet, $15/hour
*For external rates, please email the Facility Director.